Negative regulation of response to food

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to food pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN2A, OR52M1, and PTH2R, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBXN2A grouped by Negative regulation of response to food-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBXN2A →	+0.203	+1.247	<.001	<.001	3	3
CNS	OR52M1 →	+0.182	+0.253	<.001	.002	3	3
CNS	PTH2R →	-0.475	-0.265	.003	.007	3	3
BLOOD_Leukemia	CST6 →	-0.173	-1.022	<.001	.003	3	2
BLOOD_Leukemia	OR14C36 →	+0.182	+1.459	<.001	<.001	3	2
BLOOD_Leukemia	NUP160 →	+0.406	+0.992	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBXN2A by Negative regulation of response to food activity — BLOOD_Leukemia

Explore this box plot interactively →