Negative regulation of response to food

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to food pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAAL1, ANKEF1, and TCHH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to food activity versus SAAL1 in LARGE_INTESTINE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SAAL1 →	+0.899	+0.796	.002	.006	3	3
BLOOD_Lymphoma	ANKEF1 →	+1.436	+0.943	.002	.006	2	4
BLOOD_Leukemia	TCHH →	+0.457	+0.714	.007	.001	3	3
UPPER_AERODIGESTIVE_TRACT	FOS →	+3.237	+0.209	<.001	<.001	3	3
BLOOD_Lymphoma	TIMM44 →	-0.855	-1.370	<.001	.001	3	3
BLOOD_Lymphoma	AUP1 →	-0.474	-1.522	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032096 vs SAAL1 — LARGE_INTESTINE

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