Regulation of response to food

Across TCGA cell cohorts, RNA activity of the Regulation of response to food pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDAN1, NIPSNAP1, and NAT8L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDAN1 grouped by Regulation of response to food-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDAN1 →	+1.010	+1.573	.009	.005	3	4
LUNG_NSCLC_LUSC	NIPSNAP1 →	-0.799	-1.606	.001	<.001	3	3
LUNG_NSCLC_LUSC	NAT8L →	-1.638	-1.853	<.001	<.001	3	3
LUNG_NSCLC_LUSC	FOXD3 →	-0.300	-1.296	.006	.009	3	3
BLOOD_Leukemia	ERCC1 →	-0.402	-0.907	.007	.003	3	3
BLOOD_Leukemia	FAM110A →	-1.150	-1.361	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDAN1 by Regulation of response to food activity — BLOOD_Myeloma

Explore this box plot interactively →