Regulation of response to food

Across TCGA cell cohorts, RNA activity of the Regulation of response to food pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCHH, SERPINA1, and MKKS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to food activity versus TCHH in BLOOD_Leukemia (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCHH →	+0.457	+0.711	.007	.001	3	3
UPPER_AERODIGESTIVE_TRACT	SERPINA1 →	+3.638	+0.215	.008	.006	2	4
CNS	MKKS →	+0.723	+0.913	.007	.006	3	3
BLOOD_Lymphoma	NENF →	+1.037	+1.145	.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	SCN8A →	+0.856	+0.163	<.001	.007	3	3
OVARY	RANGAP1 →	-0.884	-1.072	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032095 vs TCHH — BLOOD_Leukemia

Explore this scatter interactively →