Positive regulation of protein binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2, PAICS, and ZEB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein binding activity versus DAB2 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAB2 →	+0.843	+0.243	<.001	.001	3	6
LSCC	PAICS →	-0.750	-0.203	<.001	<.001	3	6
LSCC	ZEB2 →	+0.528	+0.197	<.001	.002	3	5
LSCC	TPX2 →	-0.776	-0.271	<.001	.001	3	5
OV	LGMN →	+0.602	+0.125	<.001	<.001	3	5
OV	SRPX →	+0.966	+0.145	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032092 vs DAB2 — LSCC

Explore this scatter interactively →