Positive regulation of protein binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein binding pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD1, SLFN5, and IL15RA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein binding activity versus SOD1 in SOFT_TISSUE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SOD1 →	+0.689	+0.308	.009	.006	2	6
LARGE_INTESTINE	SLFN5 →	-1.503	-0.244	<.001	.002	3	4
BLOOD_Lymphoma	IL15RA →	-2.425	-0.611	.001	.009	3	4
LUNG_NSCLC_LUAD	RTP4 →	-0.554	-0.215	.007	.005	3	4
LUNG_SCLC	SGMS2 →	-1.093	-0.368	.003	.004	3	4
LUNG_SCLC	IQCB1 →	+0.930	+0.514	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032092 vs SOD1 — SOFT_TISSUE

Explore this scatter interactively →