Positive regulation of protein binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein binding pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GSK3B, IDE, and CAND1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein binding activity versus GSK3B in BONE (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GSK3B →	+0.912	+0.635	<.001	.009	2	9
STOMACH	IDE →	+1.014	+0.546	<.001	<.001	3	7
SKIN	CAND1 →	+0.736	+0.365	<.001	<.001	3	7
BLOOD_Leukemia	MDH1 →	+0.533	+0.256	<.001	<.001	3	7
CNS	MCM5 →	+1.045	+0.513	<.001	.008	3	7
BONE	CCT3 →	+1.074	+0.389	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032092 vs GSK3B — BONE

Explore this scatter interactively →