Positive regulation of translation in response to stress

Across TCGA patient cohorts, RNA activity of the Positive regulation of translation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA6, CTIF, and OXCT2P1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of translation in response to stress activity versus ANXA6 in GBM (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANXA6 →	-0.444	-0.256	<.001	<.001	3	5
GBM	CTIF →	-0.489	-0.245	<.001	<.001	3	4
GBM	OXCT2P1 →	-0.261	-0.166	<.001	.004	3	4
LSCC	STARD9 →	-0.324	-0.333	.008	<.001	3	4
PDAC	GNAL →	-0.225	-0.217	.003	<.001	3	4
PDAC	IGFBP7 →	-0.542	-0.238	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032056 vs ANXA6 — GBM

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