Positive regulation of translation in response to stress

Across TCGA cell cohorts, RNA activity of the Positive regulation of translation in response to stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRD5A1, GRK2, and SSH3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRD5A1 grouped by Positive regulation of translation in response to stress-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRD5A1 →	-1.042	-0.239	.004	.009	3	4
OVARY	GRK2 →	+0.442	+0.271	.004	.006	3	4
BREAST	SSH3 →	+1.035	+0.466	.001	.002	3	4
OESOPHAGUS	PHLDB3 →	+0.777	+0.270	.001	.009	2	5
BREAST	DNAJC8 →	-0.632	-0.751	.005	.003	2	4
BLOOD_Leukemia	ZC3H12B →	-0.550	-0.329	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRD5A1 by Positive regulation of translation in response to stress activity — BLOOD_Leukemia

Explore this box plot interactively →