Ciliary basal body organization

Across TCGA patient cohorts, RNA activity of the Ciliary basal body organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CROCC, WDR19, and ARHGEF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ciliary basal body organization activity versus CROCC in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CROCC →	+0.419	+0.070	<.001	.001	3	6
GBM	WDR19 →	+0.370	+0.090	<.001	<.001	3	5
GBM	ARHGEF5 →	-2.467	-0.084	.004	.008	3	5
CCRCC	TNS1_S1400 →	+0.401	+0.061	.004	<.001	3	5
CCRCC	PPM1F →	+0.263	+0.047	<.001	<.001	3	5
LUAD	CNRIP1 →	+0.174	+0.037	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032053 vs CROCC — UCEC

Explore this scatter interactively →