Ciliary basal body organization

Across TCGA patient cohorts, RNA activity of the Ciliary basal body organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRORSD1P, EZH1, and FAM161B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ciliary basal body organization activity versus PRORSD1P in COAD (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRORSD1P →	+0.372	+0.279	.002	<.001	2	5
BRCA	EZH1 →	+0.577	+0.454	<.001	<.001	3	4
BRCA	FAM161B →	+0.636	+0.441	.001	.003	3	4
BRCA	COA5 →	+0.402	+0.495	<.001	.004	3	4
CCRCC	DUSP28 →	+0.292	+0.718	<.001	<.001	3	4
BRCA	GSTM2 →	+0.949	+0.519	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032053 vs PRORSD1P — COAD

Explore this scatter interactively →