Ciliary basal body organization

Across TCGA cell cohorts, RNA activity of the Ciliary basal body organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EML4, PABPC1L, and ABHD12B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EML4 grouped by Ciliary basal body organization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EML4 →	+0.844	+0.436	.006	<.001	3	3
SOFT_TISSUE	PABPC1L →	+2.942	+0.455	<.001	.001	3	3
LUNG_NSCLC_LUAD	ABHD12B →	+0.318	+0.586	.002	.005	3	3
STOMACH	ETAA1 →	+0.867	+0.233	.003	<.001	3	3
SOFT_TISSUE	NNMT →	-5.649	-0.347	.001	.004	3	3
SOFT_TISSUE	FAM220A →	+0.497	+0.309	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EML4 by Ciliary basal body organization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →