Mitochondrial DNA metabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial DNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, FXR2, and NCBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA metabolic process activity versus SMC3 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC3 →	+0.199	+0.047	<.001	<.001	3	7
LSCC	FXR2 →	+0.233	+0.053	.001	<.001	3	6
LSCC	NCBP1 →	+0.358	+0.064	<.001	<.001	3	6
LUAD	NOLC1_S538 →	+0.578	+0.058	<.001	<.001	3	6
GBM	CKAP4_S26 →	-0.526	-0.063	<.001	<.001	3	6
LSCC	CSTF1 →	+0.190	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032042 vs SMC3 — LSCC

Explore this scatter interactively →