Mitochondrial DNA metabolic process

Across TCGA patient cohorts, RNA activity of the Mitochondrial DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, POLG2, and MEF2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA metabolic process activity versus TYMS in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TYMS →	+0.573	+0.178	<.001	.001	3	5
UCEC	POLG2 →	+0.447	+0.163	.005	.007	3	5
GBM	MEF2C →	-0.392	-0.143	.006	.001	3	5
LSCC	GPR15 →	-0.901	-0.185	.002	.001	3	4
GBM	DCST1-AS1 →	+0.665	+0.157	<.001	<.001	3	4
UCEC	NOL10 →	+0.286	+0.181	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032042 vs TYMS — LUAD

Explore this scatter interactively →