Mitochondrial DNA metabolic process

Across TCGA cell cohorts, RNA activity of the Mitochondrial DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53BP2, SPRTN, and TBX19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA metabolic process activity versus TP53BP2 in BONE (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TP53BP2 →	+0.810	+0.082	.005	.008	2	7
OVARY	SPRTN →	+0.624	+0.144	<.001	.001	3	5
LUNG_SCLC	TBX19 →	+0.683	+0.090	<.001	<.001	3	5
LUNG_SCLC	BRSK1 →	+1.222	+0.068	.009	.003	3	5
LUNG_SCLC	PDE7A →	+1.144	+0.095	<.001	<.001	3	5
SKIN	TAF5L →	+0.494	+0.171	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032042 vs TP53BP2 — BONE

Explore this scatter interactively →