Response to magnesium ion

Across TCGA patient cohorts, RNA activity of the Response to magnesium ion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JPT1, FBP1, and SMG8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to magnesium ion activity versus JPT1 in GBM (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JPT1 →	-0.442	-0.098	<.001	<.001	3	6
GBM	FBP1 →	+0.672	+0.078	<.001	<.001	3	6
CCRCC	SMG8 →	-0.146	-0.078	<.001	<.001	3	6
CCRCC	CHDH →	+0.362	+0.087	.001	.001	3	5
LSCC	CDK1 →	-0.372	-0.059	.004	<.001	3	5
LSCC	HSD17B4 →	+0.213	+0.035	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032026 vs JPT1 — GBM

Explore this scatter interactively →