Response to magnesium ion

Across TCGA cell cohorts, RNA activity of the Response to magnesium ion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF4, MRPS22, and GTF3C5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF4 grouped by Response to magnesium ion-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRPF4 →	-1.001	-1.199	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	MRPS22 →	-1.085	-1.424	.002	<.001	3	6
SOFT_TISSUE	GTF3C5 →	-0.626	-1.223	.001	.001	3	6
STOMACH	MPP6 →	-2.070	-1.007	.002	.002	3	5
SKIN	GBP1 →	-1.821	-1.060	<.001	.003	3	5
URINARY_TRACT	FAAP100 →	+0.701	+1.891	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF4 by Response to magnesium ion activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →