Response to magnesium ion

Across TCGA cell cohorts, RNA activity of the Response to magnesium ion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTDH, UCHL5, and DKK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTDH grouped by Response to magnesium ion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTDH →	+0.312	+1.772	.005	.001	3	3
BONE	UCHL5 →	+0.255	+2.111	.006	<.001	3	3
LUNG_SCLC	DKK3 →	+0.192	+1.908	.001	<.001	3	3
OESOPHAGUS	RASGRP3 →	-0.176	-1.798	.001	.001	3	3
OESOPHAGUS	ISL2 →	+0.149	+1.169	.001	.002	3	3
LARGE_INTESTINE	GNAS →	-0.269	-1.041	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTDH by Response to magnesium ion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →