Response to magnesium ion

Across TCGA cell cohorts, RNA activity of the Response to magnesium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDADC1, MECP2, and HOXC8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to magnesium ion activity versus CDADC1 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDADC1 →	+0.935	+1.131	.005	.002	3	3
LARGE_INTESTINE	MECP2 →	+0.775	+1.091	<.001	.001	3	3
LARGE_INTESTINE	HOXC8 →	+0.781	+0.894	<.001	.001	3	3
LARGE_INTESTINE	FAM50A →	+0.880	+1.187	<.001	<.001	3	3
LUNG_NSCLC_LUSC	F3 →	+6.310	+1.930	.001	.001	3	3
LUNG_NSCLC_LUSC	KRT17 →	+9.016	+1.994	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032026 vs CDADC1 — OVARY

Explore this scatter interactively →