Response to cobalt ion

Across TCGA patient cohorts, RNA activity of the Response to cobalt ion pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, CFAP20, and GNG8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cobalt ion activity versus TUBB in PDAC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TUBB →	-0.330	-0.126	.002	.004	3	4
LUAD	CFAP20 →	-0.267	-0.098	<.001	.003	3	4
OV	GNG8 →	-0.511	-0.170	.001	.004	3	3
LUAD	TPI1 →	-0.537	-0.160	<.001	<.001	3	3
LUAD	BYSL →	-0.560	-0.106	<.001	.007	2	4
BRCA	PIMREG →	-0.984	-0.426	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032025 vs TUBB — PDAC

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