Response to cobalt ion

Across TCGA cell cohorts, RNA activity of the Response to cobalt ion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGST1, LRRC63, and IFNLR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MGST1 grouped by Response to cobalt ion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MGST1 →	-6.007	-1.942	<.001	<.001	3	5
BONE	LRRC63 →	+0.860	+1.533	<.001	.002	3	4
BONE	IFNLR1 →	+1.750	+1.569	<.001	.001	3	4
LIVER	NPIPB11 →	+0.592	+1.353	.001	.001	3	4
LIVER	RGL4 →	+0.233	+1.228	.008	.005	3	4
LIVER	MEX3A →	+1.893	+1.715	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MGST1 by Response to cobalt ion activity — BLOOD_Myeloma

Explore this box plot interactively →