Response to cobalt ion

Across TCGA cell cohorts, RNA activity of the Response to cobalt ion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT8, ITGB2, and TM4SF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cobalt ion activity versus KRT8 in SKIN (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRT8 →	-1.148	-0.967	.006	.009	3	4
STOMACH	ITGB2 →	-0.867	-1.018	.001	.008	3	4
LUNG_SCLC	TM4SF1 →	-3.758	-0.941	.001	.006	3	4
BREAST	BCL7A →	+1.222	+0.739	.002	.003	3	4
BLOOD_Lymphoma	CMTM7 →	-2.526	-0.715	.001	.007	3	4
LARGE_INTESTINE	CASP3 →	+0.852	+0.785	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032025 vs KRT8 — SKIN

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