Positive regulation of insulin secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, PAQR8, and ING1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin secretion activity versus IRS2 in LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS2 →	+0.896	+0.216	<.001	<.001	3	5
GBM	PAQR8 →	+0.460	+0.139	.008	<.001	3	5
HNSC	ING1 →	+0.562	+0.176	.005	.003	3	4
HNSC	MYO16-AS1 →	+0.898	+0.143	.002	.005	3	4
LSCC	CCDC15 →	-0.423	-0.183	.008	.006	3	4
CCRCC	AKR7A2 →	-0.712	-0.484	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032024 vs IRS2 — LUAD

Explore this scatter interactively →