Positive regulation of insulin secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of insulin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS1, ZCCHC14, and RABEPK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of insulin secretion activity versus HMGCS1 in LUNG_SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HMGCS1 →	+1.280	+0.197	.001	.001	3	5
KIDNEY	ZCCHC14 →	+1.369	+0.243	.004	.002	3	5
LUNG_SCLC	RABEPK →	-0.814	-0.150	.008	<.001	3	5
LARGE_INTESTINE	PIK3R3 →	+1.379	+0.222	<.001	.003	3	4
LUNG_NSCLC_LUAD	CDCA8 →	+0.554	+0.168	.001	.005	3	4
OESOPHAGUS	IFI16 →	+3.059	+0.208	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032024 vs HMGCS1 — LUNG_SCLC

Explore this scatter interactively →