ISG15-protein conjugation

Across TCGA patient cohorts, RNA activity of the ISG15-protein conjugation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CMPK2, IFI35, and MX2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ISG15-protein conjugation activity versus CMPK2 in HNSC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CMPK2 →	+0.818	+0.119	<.001	<.001	3	10
HNSC	IFI35 →	+0.488	+0.107	<.001	<.001	3	10
HNSC	MX2 →	+0.891	+0.114	<.001	<.001	3	10
OV	NMI →	+0.549	+0.077	<.001	<.001	3	10
BRCA	STAT2 →	+0.368	+0.070	<.001	<.001	3	9
GBM	TYMP →	+0.587	+0.090	.004	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032020 vs CMPK2 — HNSC

Explore this scatter interactively →