ISG15-protein conjugation

Across TCGA cell cohorts, RNA activity of the ISG15-protein conjugation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS6, KAZALD1, and ZNF697, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INTS6 grouped by ISG15-protein conjugation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	INTS6 →	-1.009	-1.897	.002	<.001	3	5
SOFT_TISSUE	KAZALD1 →	+2.819	+1.309	.002	.005	3	4
KIDNEY	ZNF697 →	-1.157	-1.414	.001	<.001	3	4
BREAST	GHITM →	-0.491	-0.757	.005	.004	3	4
BLOOD_Leukemia	LRRC69 →	-0.790	-1.073	<.001	<.001	3	4
KIDNEY	ATP6V1H →	-0.882	-1.111	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INTS6 by ISG15-protein conjugation activity — LIVER

Explore this box plot interactively →