ISG15-protein conjugation

Across TCGA cell cohorts, RNA activity of the ISG15-protein conjugation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISG15, IFIT1, and IFIT5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ISG15-protein conjugation activity versus ISG15 in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ISG15 →	+3.447	+1.236	<.001	.005	3	5
SOFT_TISSUE	IFIT1 →	+2.950	+1.907	<.001	<.001	2	5
SOFT_TISSUE	IFIT5 →	+1.138	+1.907	<.001	<.001	3	4
LARGE_INTESTINE	BLZF1 →	+0.943	+1.900	.001	.001	3	4
LARGE_INTESTINE	NUP133 →	+1.035	+1.494	.003	<.001	3	3
BREAST	KCNQ1 →	-1.579	-2.024	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032020 vs ISG15 — BLOOD_Lymphoma

Explore this scatter interactively →