Positive regulation of TOR signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI15, RPS11P7, and GHRL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of TOR signaling activity versus PI15 in OV (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PI15 →	-0.586	-0.137	.008	.001	3	3
BRCA	RPS11P7 →	-0.987	-0.157	.003	.002	3	3
CCRCC	GHRL →	-0.349	-0.346	.005	.004	3	3
CCRCC	COL4A2-AS1 →	-0.338	-0.305	.008	.002	3	3
PDAC	PDIA3P2 →	-0.585	-0.296	.005	.003	3	3
BRCA	RN7SL225P →	-0.230	-0.137	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032008 vs PI15 — OV

Explore this scatter interactively →