Positive regulation of TOR signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAQR6, C1QL4, and EEF1B2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAQR6 grouped by Positive regulation of TOR signaling-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PAQR6 →	-0.992	-0.238	.008	.002	3	4
KIDNEY	C1QL4 →	-2.180	-0.208	.001	.008	3	4
LUNG_SCLC	EEF1B2 →	+0.756	+0.216	.002	<.001	3	4
BLOOD_Lymphoma	AEBP2 →	-1.179	-0.311	.003	.006	3	4
CNS	NKAPD1 →	-0.471	-0.161	.004	.007	3	4
STOMACH	AP5S1 →	+0.972	+0.094	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAQR6 by Positive regulation of TOR signaling activity — SOFT_TISSUE

Explore this box plot interactively →