Positive regulation of TOR signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of TOR signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKG1, LNX2, and KCNJ10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKG1 grouped by Positive regulation of TOR signaling-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRKG1 →	-0.147	-0.138	.005	.007	2	4
LUNG_NSCLC_LUSC	LNX2 →	-0.406	-0.178	.003	.001	3	3
KIDNEY	KCNJ10 →	+0.380	+0.250	.001	.004	3	3
KIDNEY	RALBP1 →	-0.265	-0.235	<.001	<.001	3	3
BLOOD_Leukemia	ETS1 →	+0.235	+0.260	.003	<.001	2	3
BLOOD_Leukemia	SLC5A11 →	+0.145	+0.264	.005	.003	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKG1 by Positive regulation of TOR signaling activity — SKIN

Explore this box plot interactively →