Negative regulation of TOR signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNA, SMPD1, and VEGFA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMNA grouped by Negative regulation of TOR signaling-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LMNA →	-2.799	-0.195	.002	.007	3	3
BLOOD_Leukemia	SMPD1 →	-1.047	-0.193	.003	.003	3	3
SOFT_TISSUE	VEGFA →	+2.595	+0.341	.002	.001	3	3
LUNG_NSCLC_LUSC	PROB1 →	-0.856	-0.208	<.001	.004	3	3
BLOOD_Leukemia	NSMCE4A →	+0.715	+0.195	<.001	<.001	3	2
BLOOD_Leukemia	VAT1 →	-1.628	-0.248	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMNA by Negative regulation of TOR signaling activity — BLOOD_Leukemia

Explore this box plot interactively →