Negative regulation of TOR signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGCB, ENDOG, and TMC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of TOR signaling activity versus SGCB in STOMACH (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SGCB →	-1.016	-0.194	.004	.001	3	4
LIVER	ENDOG →	+0.748	+0.257	.004	<.001	3	4
BREAST	TMC4 →	+2.330	+0.175	<.001	<.001	3	3
BREAST	CSRP2 →	-1.778	-0.133	<.001	<.001	3	3
BREAST	ADM5 →	+0.721	+0.145	.007	.001	3	3
LUNG_NSCLC_LUAD	TMCC2 →	-0.993	-0.357	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032007 vs SGCB — STOMACH

Explore this scatter interactively →