Negative regulation of fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid beta-oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGR, S100A4, and XIRP1_S295, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid beta-oxidation activity versus FGR in BRCA (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGR →	-0.552	-0.045	<.001	.005	3	5
COAD	S100A4 →	-0.526	-0.029	<.001	.001	3	4
BRCA	XIRP1_S295 →	-1.557	-0.066	<.001	<.001	3	4
BRCA	IL4I1 →	-0.451	-0.046	.007	.001	3	4
PDAC	NCF1_S348 →	-0.852	-0.068	.002	<.001	3	4
BRCA	PML →	-0.277	-0.041	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031999 vs FGR — BRCA

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