Negative regulation of fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Negative regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, WDFY4, and IL16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fatty acid beta-oxidation activity versus CNRIP1 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.899	+0.943	<.001	<.001	3	6
HNSC	WDFY4 →	+0.623	+0.575	.002	<.001	3	5
OV	IL16 →	+0.756	+0.425	<.001	.008	3	5
OV	ARHGAP45 →	+0.656	+0.364	.001	.008	3	5
BRCA	ACSM5 →	+0.706	+0.846	<.001	<.001	3	5
BRCA	SH2D3C →	+0.744	+0.948	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031999 vs CNRIP1 — BRCA

Explore this scatter interactively →