Negative regulation of fatty acid beta-oxidation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXL22, MPDZ, and LRRC75A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXL22 grouped by Negative regulation of fatty acid beta-oxidation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FBXL22 →	+0.541	+0.995	<.001	<.001	3	5
LUNG_SCLC	MPDZ →	-1.017	-0.941	.007	.002	3	4
CNS	LRRC75A →	-1.200	-1.261	.003	.004	3	4
OVARY	PAQR5 →	-1.307	-1.245	.008	.002	3	4
LUNG_SCLC	SH3GL2 →	-3.164	-1.122	.007	.009	3	3
LUNG_SCLC	TIAM2 →	-1.302	-1.294	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXL22 by Negative regulation of fatty acid beta-oxidation activity — BREAST

Explore this box plot interactively →