Regulation of fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid beta-oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MARCKSL1, CHAF1A_S775, and EIF4G1_S1231, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid beta-oxidation activity versus MARCKSL1 in CCRCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MARCKSL1 →	-0.401	-0.037	.003	.009	3	5
LUAD	CHAF1A_S775 →	-0.718	-0.055	.009	.004	3	5
UCEC	EIF4G1_S1231 →	-0.350	-0.052	.004	.003	3	5
UCEC	JPT1_S131 →	-0.661	-0.074	<.001	<.001	3	5
LUAD	LARP4_S722 →	-0.505	-0.055	<.001	<.001	3	5
LUAD	BAZ1A →	-0.337	-0.039	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031998 vs MARCKSL1 — CCRCC

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