Regulation of fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, ANKRD10, and EFNB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid beta-oxidation activity versus IRS2 in LUAD (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS2 →	+1.628	+0.946	<.001	<.001	3	10
OV	ANKRD10 →	+0.866	+0.555	<.001	.004	3	6
PDAC	EFNB2 →	+0.564	+0.558	.003	.005	3	5
CCRCC	IDH2 →	-0.490	-1.075	<.001	<.001	3	5
COAD	CLN5 →	+0.148	+0.429	.007	.001	3	5
BRCA	IRS1 →	+1.136	+0.750	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031998 vs IRS2 — LUAD

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