Response to corticosteroid

Across TCGA patient cohorts, RNA activity of the Response to corticosteroid pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, TIMP2, and CDC5L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosteroid activity versus EIF3G in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EIF3G →	-0.249	-0.043	<.001	<.001	3	9
BRCA	TIMP2 →	+1.084	+0.043	<.001	<.001	3	8
GBM	CDC5L →	-0.272	-0.041	<.001	<.001	3	8
BRCA	CTHRC1 →	+1.077	+0.038	<.001	<.001	3	8
BRCA	AEBP1 →	+0.906	+0.036	<.001	<.001	3	8
GBM	RBM25 →	-0.355	-0.037	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031960 vs EIF3G — GBM

Explore this scatter interactively →