Response to corticosteroid

Across TCGA patient cohorts, RNA activity of the Response to corticosteroid pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLAD1, IDH3B, and CEP192, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosteroid activity versus FLAD1 in LSCC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FLAD1 →	-0.407	-0.133	.004	.001	3	6
LSCC	IDH3B →	-0.498	-0.122	<.001	.001	3	5
LSCC	CEP192 →	-0.346	-0.094	.001	.001	3	5
GBM	ASF1B →	-0.691	-0.084	.001	.006	3	5
LSCC	EZH2 →	-0.752	-0.124	<.001	.001	3	5
LSCC	FANCL →	-0.527	-0.138	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031960 vs FLAD1 — LSCC

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