Response to corticosteroid

Across TCGA cell cohorts, RNA activity of the Response to corticosteroid pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, SRSF1, and XRCC2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosteroid activity versus ZFP36 in OESOPHAGUS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZFP36 →	+2.246	+0.094	<.001	<.001	3	14
BREAST	SRSF1 →	-0.611	-0.083	.009	.001	3	14
BONE	XRCC2 →	-1.897	-0.100	<.001	<.001	3	14
LARGE_INTESTINE	EME1 →	-1.158	-0.074	<.001	<.001	3	14
OVARY	ILF3 →	-0.744	-0.110	<.001	<.001	3	13
BONE	CEP78 →	-0.960	-0.068	.003	.003	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031960 vs ZFP36 — OESOPHAGUS

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