Response to corticosteroid

Across TCGA cell cohorts, RNA activity of the Response to corticosteroid pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSEN2, TLE6, and TMEM205, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticosteroid activity versus PSEN2 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PSEN2 →	+0.997	+0.214	.003	.002	3	5
LUNG_NSCLC_LUAD	TLE6 →	+1.486	+0.178	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TMEM205 →	+0.994	+0.192	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ATRAID →	+0.432	+0.130	.001	.003	3	4
LUNG_NSCLC_LUAD	TOB1 →	+0.816	+0.122	.005	.005	3	4
SOFT_TISSUE	G3BP1 →	-0.706	-0.268	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031960 vs PSEN2 — OESOPHAGUS

Explore this scatter interactively →