Intracellular corticosteroid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular corticosteroid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNE1, SEPTIN4, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular corticosteroid receptor signaling pathway activity versus SYNE1 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNE1 →	+0.424	+0.090	<.001	<.001	3	8
CCRCC	SEPTIN4 →	+0.481	+0.068	<.001	<.001	3	8
UCEC	RSU1 →	+0.481	+0.065	<.001	.003	3	7
OV	CLPX →	-0.296	-0.068	<.001	.001	3	7
BRCA	CNRIP1 →	+0.704	+0.077	<.001	<.001	3	7
GBM	RPL30 →	-0.286	-0.091	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031958 vs SYNE1 — LSCC

Explore this scatter interactively →