Intracellular corticosteroid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Intracellular corticosteroid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VSIG10L, IK, and SPATA9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular corticosteroid receptor signaling pathway activity versus VSIG10L in CCRCC (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VSIG10L →	-0.299	-0.685	.001	.001	3	3
GBM	IK →	+0.139	+0.524	.007	.002	3	3
GBM	SPATA9 →	+0.285	+0.613	.003	.003	3	3
PDAC	LINC01213 →	-0.113	-0.602	.005	.001	3	3
PDAC	ABCF2 →	-0.141	-0.541	.005	.005	3	3
PDAC	SULT2B1 →	-0.840	-0.781	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031958 vs VSIG10L — CCRCC

Explore this scatter interactively →