Intracellular corticosteroid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Intracellular corticosteroid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCXR, CDC37L1, and TMEM241, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCXR grouped by Intracellular corticosteroid receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DCXR →	+0.633	+0.752	.002	.001	3	5
LUNG_NSCLC_LUSC	CDC37L1 →	-0.856	-0.829	.006	.009	2	5
LUNG_NSCLC_LUAD	TMEM241 →	+0.794	+0.599	<.001	.002	3	3
OVARY	TXNIP →	-2.187	-1.000	.002	<.001	3	3
LUNG_SCLC	RPS6KA4 →	+1.329	+1.502	<.001	<.001	3	3
PANCREAS	DHTKD1 →	+0.712	+1.098	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCXR by Intracellular corticosteroid receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →