Intracellular corticosteroid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Intracellular corticosteroid receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YWHAH, ZC3H7B, and PPP6R2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular corticosteroid receptor signaling pathway activity versus YWHAH in BLOOD_Lymphoma (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	YWHAH →	+1.078	+0.184	<.001	<.001	3	5
CNS	ZC3H7B →	+0.859	+0.273	<.001	<.001	3	4
SKIN	PPP6R2 →	+1.267	+0.297	.005	.005	3	4
SKIN	AP1B1 →	+0.777	+0.234	.004	.001	3	4
SKIN	ZFP62 →	-1.001	-0.338	.007	<.001	3	4
SKIN	DAPK1 →	+2.061	+0.284	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031958 vs YWHAH — BLOOD_Lymphoma

Explore this scatter interactively →