Regulation of protein autophosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein autophosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, FLNA_S2152, and ILK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein autophosphorylation activity versus VCL in UCEC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VCL →	+0.540	+0.082	<.001	<.001	3	10
OV	FLNA_S2152 →	+1.051	+0.072	<.001	<.001	3	10
UCEC	ILK →	+0.537	+0.067	<.001	.001	3	10
LSCC	TIMP3 →	+0.848	+0.076	<.001	<.001	3	9
COAD	RFC1_T506 →	-0.863	-0.031	<.001	.004	3	9
UCEC	RSU1 →	+0.425	+0.059	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031952 vs VCL — UCEC

Explore this scatter interactively →