Regulation of protein autophosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLPI, TNKS1BP1, and KIAA1958, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein autophosphorylation activity versus SLPI in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLPI →	+1.574	+0.213	<.001	<.001	3	7
HNSC	TNKS1BP1 →	+0.683	+0.319	<.001	<.001	3	6
HNSC	KIAA1958 →	-0.500	-0.186	.001	.004	3	6
GBM	CARMIL3 →	-0.780	-0.283	<.001	<.001	3	6
LUAD	MPZL2 →	+0.597	+0.161	.007	.001	3	6
GBM	ANXA2 →	+0.931	+0.316	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031952 vs SLPI — UCEC

Explore this scatter interactively →