Regulation of protein autophosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH4A1, AAMDC, and ZNF697, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein autophosphorylation activity versus ALDH4A1 in LUNG_NSCLC_LUAD (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ALDH4A1 →	+1.027	+1.009	.001	.005	3	3
OESOPHAGUS	AAMDC →	+1.183	+1.542	.005	<.001	3	3
OESOPHAGUS	ZNF697 →	-1.238	-1.542	.005	<.001	3	3
OVARY	IDI1 →	+1.495	+1.633	.008	.002	3	3
OESOPHAGUS	PPRC1 →	-1.022	-1.542	.002	<.001	3	3
OESOPHAGUS	CD14 →	+1.774	+1.542	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031952 vs ALDH4A1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →