TOR signaling

Across TCGA cell cohorts, RNA activity of the TOR signaling pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYS1, FAM122B, and ADIPOR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GYS1 grouped by TOR signaling-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GYS1 →	+0.796	+0.335	.004	.004	3	5
LUNG_NSCLC_LUSC	FAM122B →	-0.933	-0.162	.002	<.001	3	4
LARGE_INTESTINE	ADIPOR2 →	-0.541	-0.314	.001	.003	3	4
BREAST	PER2 →	+1.024	+0.244	<.001	<.001	3	4
KIDNEY	FNDC3B →	+0.898	+0.358	.003	<.001	3	4
LIVER	CDC34 →	-0.991	-0.390	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GYS1 by TOR signaling activity — SOFT_TISSUE

Explore this box plot interactively →