Protection from non-homologous end joining at telomere

Across TCGA patient cohorts, RNA activity of the Protection from non-homologous end joining at telomere pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFAP4, GINS1, and TTI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protection from non-homologous end joining at telomere activity versus TFAP4 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TFAP4 →	+0.348	+0.210	<.001	<.001	3	7
GBM	GINS1 →	+0.625	+0.353	<.001	<.001	3	6
LSCC	TTI1 →	+0.423	+0.193	.001	.001	3	6
LSCC	URB2 →	+0.614	+0.272	<.001	<.001	3	6
GBM	C21orf58 →	+0.901	+0.527	<.001	.001	3	6
GBM	DBF4B →	+0.616	+0.535	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031848 vs TFAP4 — LSCC

Explore this scatter interactively →